Drug interactions
Halofenate + Tolbutamide
Severity: Minor
Halofenate and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Halofenate, an investigational lipid-lowering and uricosuric agent, has been reported to potentiate sulfonylurea effects. It is not marketed, so practical relevance is limited.
What this interaction means in plain words
Halofenate and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possibly reduced tolbutamide metabolism or increased glucose lowering; the mechanism is not clearly established.
What to do
Monitor blood glucose if halofenate is used in a research setting and adjust the tolbutamide dose accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Halofenate with Tolbutamide?
MediHelp rates the interaction as minor. Halofenate and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Halofenate, an investigational lipid-lowering and uricosuric agent, has been reported to potentiate sulfonylurea effects. It is not marketed, so practical relevance is limited.
How serious is the interaction between Halofenate and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose if halofenate is used in a research setting and adjust the tolbutamide dose accordingly.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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