Drug interactions
Halothane + Methohexital
Severity: Moderate
Halothane and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates and halothane both depress the central nervous and cardiovascular systems, which can cause additive hypotension and respiratory depression. Barbiturate-induced enzyme induction may also increase production of halothane metabolites.
What this interaction means in plain words
Halothane and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Halothane belongs to Central Nervous System; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS and cardiovascular depression, with possible hepatic enzyme induction.
What to do
Reduce doses as needed and monitor blood pressure, ventilation and ECG during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methohexital
Frequently asked questions
Can I take Halothane with Methohexital?
MediHelp rates the interaction as moderate. Halothane and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates and halothane both depress the central nervous and cardiovascular systems, which can cause additive hypotension and respiratory depression. Barbiturate-induced enzyme induction may also increase production of halothane metabolites.
How serious is the interaction between Halothane and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce doses as needed and monitor blood pressure, ventilation and ECG during anesthesia.
What other medicines interact with Methohexital?
MediHelp also lists interactions of Methohexital with, for example, Alprazolam, Amobarbital, Buprenorphine. The full list is on the Methohexital page.
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