Drug interactions
Henbane + Maprotiline
Severity: Moderate
Henbane and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains hyoscyamine and scopolamine, which are potent antimuscarinic alkaloids. Together with maprotiline, anticholinergic effects may be considerably increased, causing delirium, tachycardia, urinary retention and hyperthermia.
What this interaction means in plain words
Henbane and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic activity from tropane alkaloids and the anticholinergic tricyclic-like antidepressant.
What to do
Avoid combining where possible, since herbal alkaloid content is variable. If used, monitor for anticholinergic toxicity including confusion, tachycardia and urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Henbane with Maprotiline?
MediHelp rates the interaction as moderate. Henbane and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Henbane contains hyoscyamine and scopolamine, which are potent antimuscarinic alkaloids. Together with maprotiline, anticholinergic effects may be considerably increased, causing delirium, tachycardia, urinary retention and hyperthermia.
How serious is the interaction between Henbane and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, since herbal alkaloid content is variable. If used, monitor for anticholinergic toxicity including confusion, tachycardia and urinary retention.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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