Drug interactions
Henbane + Memantine-donepezil
Severity: Moderate
Henbane and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains hyoscyamine and scopolamine, which are anticholinergic and oppose the effect of donepezil. The anticholinergic activity can worsen cognition in dementia and negate the benefit of the cholinesterase inhibitor.
What this interaction means in plain words
Henbane and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism between muscarinic antagonist alkaloids and a cholinesterase inhibitor.
What to do
Avoid henbane in patients with dementia taking donepezil. Choose a non-anticholinergic alternative for the indication.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Frequently asked questions
Can I take Henbane with Memantine-donepezil?
MediHelp rates the interaction as moderate. Henbane and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Henbane contains hyoscyamine and scopolamine, which are anticholinergic and oppose the effect of donepezil. The anticholinergic activity can worsen cognition in dementia and negate the benefit of the cholinesterase inhibitor.
How serious is the interaction between Henbane and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid henbane in patients with dementia taking donepezil. Choose a non-anticholinergic alternative for the indication.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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