Drug interactions
Henbane + Quetiapine
Severity: Moderate
Henbane and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains antimuscarinic alkaloids such as hyoscyamine and scopolamine, which add to the anticholinergic activity of quetiapine. This can cause confusion, constipation, urinary retention, tachycardia and dry mouth.
What this interaction means in plain words
Henbane and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Avoid the herbal product where possible, or monitor for anticholinergic toxicity and delirium, especially in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Henbane with Quetiapine?
MediHelp rates the interaction as moderate. Henbane and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Henbane contains antimuscarinic alkaloids such as hyoscyamine and scopolamine, which add to the anticholinergic activity of quetiapine. This can cause confusion, constipation, urinary retention, tachycardia and dry mouth.
How serious is the interaction between Henbane and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the herbal product where possible, or monitor for anticholinergic toxicity and delirium, especially in older adults.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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