Drug interactions
Henbane + Ziprasidone
Severity: Moderate
Henbane and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains hyoscyamine and scopolamine, which are antimuscarinic alkaloids and may add to the weak anticholinergic effects of ziprasidone. This can cause confusion, constipation, urinary retention, tachycardia and heat intolerance.
What this interaction means in plain words
Henbane and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Avoid the combination where possible, particularly in older adults. Monitor for anticholinergic toxicity and delirium if both are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Henbane with Ziprasidone?
MediHelp rates the interaction as moderate. Henbane and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Henbane contains hyoscyamine and scopolamine, which are antimuscarinic alkaloids and may add to the weak anticholinergic effects of ziprasidone. This can cause confusion, constipation, urinary retention, tachycardia and heat intolerance.
How serious is the interaction between Henbane and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, particularly in older adults. Monitor for anticholinergic toxicity and delirium if both are used.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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