Drug interactions
Heparin + Irbesartan
Severity: Moderate
Heparin and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparin can suppress adrenal aldosterone production and cause hyperkalemia, even at low doses over several days. When given with irbesartan, which reduces renal potassium excretion, the risk is additive.
What this interaction means in plain words
Heparin and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Heparin belongs to Cardiovascular; Irbesartan belongs to Cardiovascular.
Why it happens
Heparin-induced inhibition of aldosterone synthesis added to angiotensin receptor blockade, reducing renal potassium excretion.
What to do
Monitor serum potassium during prolonged heparin therapy, especially with renal impairment or diabetes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Heparin with Irbesartan?
MediHelp rates the interaction as moderate. Heparin and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparin can suppress adrenal aldosterone production and cause hyperkalemia, even at low doses over several days. When given with irbesartan, which reduces renal potassium excretion, the risk is additive.
How serious is the interaction between Heparin and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium during prolonged heparin therapy, especially with renal impairment or diabetes.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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