Drug interactions
Heparin + Roxithromycin
Severity: Minor
Heparin and Roxithromycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Roxithromycin is not known to alter heparin clearance in a clinically important way, because heparin is cleared by the reticuloendothelial system and renal routes rather than CYP enzymes. Any interaction is theoretical.
What this interaction means in plain words
Heparin and Roxithromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Heparin belongs to Cardiovascular; Roxithromycin belongs to Anti Bacterial.
Why it happens
No established mechanism; heparin is not metabolized by CYP enzymes.
What to do
No adjustment is required; monitor aPTT or anti-Xa as part of routine heparin therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Other interactions of Roxithromycin
- Digoxin + Roxithromycin Major
- Argatroban + Roxithromycin Moderate
- Cyclosporin + Roxithromycin Moderate
- Roxithromycin + Tacrolimus Moderate
- Ampicillin-sulbactam + Roxithromycin Minor
- Ampicillin + Roxithromycin Minor
Frequently asked questions
Can I take Heparin with Roxithromycin?
MediHelp rates the interaction as minor. Heparin and Roxithromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Roxithromycin is not known to alter heparin clearance in a clinically important way, because heparin is cleared by the reticuloendothelial system and renal routes rather than CYP enzymes. Any interaction is theoretical.
How serious is the interaction between Heparin and Roxithromycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is required; monitor aPTT or anti-Xa as part of routine heparin therapy.
What other medicines interact with Heparin?
MediHelp also lists interactions of Heparin with, for example, Defibrotide, Ketorolac, Oritavancin. The full list is on the Heparin page.
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