Drug interactions
Argatroban + Roxithromycin
Severity: Moderate
Argatroban and Roxithromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Roxithromycin might raise argatroban exposure and so increase anticoagulant effect and bleeding risk. The effect is predicted rather than well documented, because argatroban is cleared mainly through hepatobiliary metabolism with only a minor CYP3A4 contribution.
What this interaction means in plain words
Argatroban and Roxithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Roxithromycin belongs to Anti Bacterial.
Why it happens
Weak CYP3A4 inhibition by roxithromycin may modestly reduce argatroban metabolism.
What to do
Monitor aPTT or ACT and adjust the argatroban infusion to target range when starting or stopping roxithromycin. Watch for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Other interactions of Roxithromycin
- Digoxin + Roxithromycin Major
- Cyclosporin + Roxithromycin Moderate
- Roxithromycin + Tacrolimus Moderate
- Ampicillin-sulbactam + Roxithromycin Minor
- Ampicillin + Roxithromycin Minor
- Balsalazide + Roxithromycin Minor
Frequently asked questions
Can I take Argatroban with Roxithromycin?
MediHelp rates the interaction as moderate. Argatroban and Roxithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Roxithromycin might raise argatroban exposure and so increase anticoagulant effect and bleeding risk. The effect is predicted rather than well documented, because argatroban is cleared mainly through hepatobiliary metabolism with only a minor CYP3A4 contribution.
How serious is the interaction between Argatroban and Roxithromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor aPTT or ACT and adjust the argatroban infusion to target range when starting or stopping roxithromycin. Watch for bleeding.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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