Drug interactions
Ampicillin + Roxithromycin
Severity: Minor
Ampicillin and Roxithromycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Roxithromycin is a bacteriostatic macrolide and may theoretically reduce the bactericidal effect of ampicillin. Clinical significance is unproven.
What this interaction means in plain words
Ampicillin and Roxithromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ampicillin belongs to Anti Bacterial; Roxithromycin belongs to Anti Bacterial.
Why it happens
Pharmacodynamic antagonism: growth inhibition reduces killing by cell-wall-active beta-lactams.
What to do
No routine change; monitor clinical response in severe infections.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ampicillin
- Allopurinol + Ampicillin Moderate
- Ampicillin + Bcg vaccine live Moderate
- Ampicillin + Chloramphenicol Moderate
- Ampicillin + Chloroquine Moderate
- Ampicillin + Cholera vaccine Moderate
- Ampicillin + Demeclocycline Moderate
Other interactions of Roxithromycin
- Digoxin + Roxithromycin Major
- Argatroban + Roxithromycin Moderate
- Cyclosporin + Roxithromycin Moderate
- Roxithromycin + Tacrolimus Moderate
- Ampicillin-sulbactam + Roxithromycin Minor
- Balsalazide + Roxithromycin Minor
Frequently asked questions
Can I take Ampicillin with Roxithromycin?
MediHelp rates the interaction as minor. Ampicillin and Roxithromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Roxithromycin is a bacteriostatic macrolide and may theoretically reduce the bactericidal effect of ampicillin. Clinical significance is unproven.
How serious is the interaction between Ampicillin and Roxithromycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change; monitor clinical response in severe infections.
What other medicines interact with Ampicillin?
MediHelp also lists interactions of Ampicillin with, for example, Allopurinol, Bcg vaccine live, Chloramphenicol. The full list is on the Ampicillin page.
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