Drug interactions
Heparin + Ticagrelor
Severity: Moderate
Heparin and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticagrelor inhibits platelet aggregation and heparin inhibits clotting, so together they increase the likelihood of bleeding. The combination is common in acute coronary syndrome and PCI, where the benefit is accepted but bleeding must be watched.
What this interaction means in plain words
Heparin and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Heparin belongs to Cardiovascular; Ticagrelor belongs to Cardiovascular.
Why it happens
Additive hemostatic impairment through P2Y12 platelet receptor blockade plus antithrombin-mediated inhibition of thrombin and factor Xa.
What to do
Monitor for bleeding and follow hemoglobin, platelets and aPTT or anti-Xa levels as indicated. Limit heparin duration and dose to the clinical indication.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Heparin with Ticagrelor?
MediHelp rates the interaction as moderate. Heparin and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticagrelor inhibits platelet aggregation and heparin inhibits clotting, so together they increase the likelihood of bleeding. The combination is common in acute coronary syndrome and PCI, where the benefit is accepted but bleeding must be watched.
How serious is the interaction between Heparin and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and follow hemoglobin, platelets and aPTT or anti-Xa levels as indicated. Limit heparin duration and dose to the clinical indication.
What other medicines interact with Heparin?
MediHelp also lists interactions of Heparin with, for example, Defibrotide, Ketorolac, Oritavancin. The full list is on the Heparin page.
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