Drug interactions
Hepatitis a / b vaccine + Prednisone
Severity: Moderate
Hepatitis a / b vaccine and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppressive doses of prednisone can lessen the antibody response to this inactivated combined vaccine. The vaccine is not live, so the concern is reduced protection.
What this interaction means in plain words
Hepatitis a / b vaccine and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoid-mediated immunosuppression blunting vaccine response.
What to do
Vaccinate before starting prednisone where feasible, and otherwise vaccinate and check anti-HBs titres afterwards in high-risk patients, revaccinating if non-responsive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Hepatitis a / b vaccine with Prednisone?
MediHelp rates the interaction as moderate. Hepatitis a / b vaccine and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Immunosuppressive doses of prednisone can lessen the antibody response to this inactivated combined vaccine. The vaccine is not live, so the concern is reduced protection.
How serious is the interaction between Hepatitis a / b vaccine and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting prednisone where feasible, and otherwise vaccinate and check anti-HBs titres afterwards in high-risk patients, revaccinating if non-responsive.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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