Drug interactions
Hepatitis a / b vaccine + Procarbazine
Severity: Moderate
Hepatitis a / b vaccine and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine can suppress the immune system and reduce the antibody response to this inactivated combined vaccine, risking inadequate protection.
What this interaction means in plain words
Hepatitis a / b vaccine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-induced immunosuppression reduces vaccine immunogenicity.
What to do
Complete vaccination at least 2 weeks before starting procarbazine if possible. Otherwise revaccinate at least 3 months after therapy and check antibody titers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Hepatitis a / b vaccine with Procarbazine?
MediHelp rates the interaction as moderate. Hepatitis a / b vaccine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine can suppress the immune system and reduce the antibody response to this inactivated combined vaccine, risking inadequate protection.
How serious is the interaction between Hepatitis a / b vaccine and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete vaccination at least 2 weeks before starting procarbazine if possible. Otherwise revaccinate at least 3 months after therapy and check antibody titers.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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