Drug interactions
Hepatitis a / b vaccine + Ustekinumab
Severity: Moderate
Hepatitis a / b vaccine and Ustekinumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ustekinumab may blunt the antibody response to inactivated vaccines. Protection after vaccination may therefore be incomplete.
What this interaction means in plain words
Hepatitis a / b vaccine and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Immunomodulation through IL-12/23 inhibition may reduce vaccine immune response.
What to do
Where possible, give the vaccine series before starting ustekinumab. Otherwise consider checking anti-HBs titers after vaccination and revaccinating if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Frequently asked questions
Can I take Hepatitis a / b vaccine with Ustekinumab?
MediHelp rates the interaction as moderate. Hepatitis a / b vaccine and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ustekinumab may blunt the antibody response to inactivated vaccines. Protection after vaccination may therefore be incomplete.
How serious is the interaction between Hepatitis a / b vaccine and Ustekinumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, give the vaccine series before starting ustekinumab. Otherwise consider checking anti-HBs titers after vaccination and revaccinating if the response is inadequate.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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