Drug interactions
Hepatitis a / typhoid vaccine + Prednisone
Severity: Minor
Hepatitis a / typhoid vaccine and Prednisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppressive doses of prednisone can lessen the response to inactivated hepatitis A and parenteral typhoid vaccine. The vaccine is not live, so the concern is reduced protection.
What this interaction means in plain words
Hepatitis a / typhoid vaccine and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Glucocorticoid-mediated immunosuppression blunting vaccine response.
What to do
Vaccinate before travel where possible, ideally before starting high-dose steroids, and reinforce food and water precautions if the patient is immunosuppressed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Hepatitis a / typhoid vaccine with Prednisone?
MediHelp rates the interaction as minor. Hepatitis a / typhoid vaccine and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Immunosuppressive doses of prednisone can lessen the response to inactivated hepatitis A and parenteral typhoid vaccine. The vaccine is not live, so the concern is reduced protection.
How serious is the interaction between Hepatitis a / typhoid vaccine and Prednisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before travel where possible, ideally before starting high-dose steroids, and reinforce food and water precautions if the patient is immunosuppressed.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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