Drug interactions
Hepatitis a / typhoid vaccine + Ustekinumab
Severity: Moderate
Hepatitis a / typhoid vaccine and Ustekinumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ustekinumab may reduce the immune response to inactivated vaccines. Protection against hepatitis A or typhoid may be lower than expected, which matters for travelers.
What this interaction means in plain words
Hepatitis a / typhoid vaccine and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Immunomodulation through IL-12/23 inhibition may reduce vaccine immune response.
What to do
Vaccinate before starting ustekinumab when feasible. Continue food and water hygiene precautions and consider serologic checks for hepatitis A.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hepatitis a / typhoid vaccine and Ustekinumab, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Frequently asked questions
Can I take Hepatitis a / typhoid vaccine with Ustekinumab?
MediHelp rates the interaction as moderate. Hepatitis a / typhoid vaccine and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ustekinumab may reduce the immune response to inactivated vaccines. Protection against hepatitis A or typhoid may be lower than expected, which matters for travelers.
How serious is the interaction between Hepatitis a / typhoid vaccine and Ustekinumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting ustekinumab when feasible. Continue food and water hygiene precautions and consider serologic checks for hepatitis A.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
