Drug interactions
Hepatitis A vaccine inactivated + Procarbazine
Severity: Moderate
Hepatitis A vaccine inactivated and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine is myelosuppressive and immunosuppressive, so antibody response to the inactivated hepatitis A vaccine may be reduced. The vaccine is not harmful but protection may be inadequate.
What this interaction means in plain words
Hepatitis A vaccine inactivated and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hepatitis A vaccine inactivated belongs to Anti Virals; Procarbazine belongs to Oncology.
Why it happens
Immunosuppression from procarbazine blunts the vaccine immune response.
What to do
Vaccinate at least 2 weeks before starting chemotherapy where possible. If given during or shortly before therapy, consider revaccination several months after treatment ends, and check serology if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Other interactions of Hepatitis A vaccine inactivated
- Adalimumab + Hepatitis A vaccine inactivated Moderate
- Alefacept + Hepatitis A vaccine inactivated Moderate
- Anakinra + Hepatitis A vaccine inactivated Moderate
- Anti-thymocyte + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin equine + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin rabbit + Hepatitis A vaccine inactivated Moderate
Frequently asked questions
Can I take Hepatitis A vaccine inactivated with Procarbazine?
MediHelp rates the interaction as moderate. Hepatitis A vaccine inactivated and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine is myelosuppressive and immunosuppressive, so antibody response to the inactivated hepatitis A vaccine may be reduced. The vaccine is not harmful but protection may be inadequate.
How serious is the interaction between Hepatitis A vaccine inactivated and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before starting chemotherapy where possible. If given during or shortly before therapy, consider revaccination several months after treatment ends, and check serology if needed.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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