Drug interactions
Hepatitis A vaccine inactivated + Ustekinumab
Severity: Minor
Hepatitis A vaccine inactivated and Ustekinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ustekinumab may blunt the antibody response to inactivated vaccines, which could leave patients less protected. The vaccine is safe to give, but its effectiveness may be reduced.
What this interaction means in plain words
Hepatitis A vaccine inactivated and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hepatitis A vaccine inactivated belongs to Anti Virals; Ustekinumab belongs to Gastrointestinal Tract.
Why it happens
IL-12/23 inhibition may reduce immune responses to vaccine antigens.
What to do
Where possible, give the vaccine before starting ustekinumab. If given during therapy, consider checking antibody titers in high-risk patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Other interactions of Hepatitis A vaccine inactivated
- Adalimumab + Hepatitis A vaccine inactivated Moderate
- Alefacept + Hepatitis A vaccine inactivated Moderate
- Anakinra + Hepatitis A vaccine inactivated Moderate
- Anti-thymocyte + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin equine + Hepatitis A vaccine inactivated Moderate
- Antithymocyte globulin rabbit + Hepatitis A vaccine inactivated Moderate
Frequently asked questions
Can I take Hepatitis A vaccine inactivated with Ustekinumab?
MediHelp rates the interaction as minor. Hepatitis A vaccine inactivated and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ustekinumab may blunt the antibody response to inactivated vaccines, which could leave patients less protected. The vaccine is safe to give, but its effectiveness may be reduced.
How serious is the interaction between Hepatitis A vaccine inactivated and Ustekinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, give the vaccine before starting ustekinumab. If given during therapy, consider checking antibody titers in high-risk patients.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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