Drug interactions
Hepatitis b vaccine + Ustekinumab
Severity: Minor
Hepatitis b vaccine and Ustekinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hepatitis B vaccine is non-live and safe with ustekinumab, and responses are generally preserved though may be somewhat lower in some patients.
What this interaction means in plain words
Hepatitis b vaccine and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic: IL-12/23 inhibition may slightly reduce vaccine responses.
What to do
Vaccinate as indicated and check anti-HBs titres afterwards in high-risk patients, revaccinating if inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Frequently asked questions
Can I take Hepatitis b vaccine with Ustekinumab?
MediHelp rates the interaction as minor. Hepatitis b vaccine and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hepatitis B vaccine is non-live and safe with ustekinumab, and responses are generally preserved though may be somewhat lower in some patients.
How serious is the interaction between Hepatitis b vaccine and Ustekinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate as indicated and check anti-HBs titres afterwards in high-risk patients, revaccinating if inadequate.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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