Drug interactions
Histrelin + Lithium
Severity: Minor
Histrelin and Lithium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin is a GnRH agonist, and androgen deprivation therapies can prolong the QT interval. Lithium can also affect cardiac repolarization, so the combination may have an additive effect. The clinical significance is probably small in most patients.
What this interaction means in plain words
Histrelin and Lithium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Histrelin belongs to Musculoskeletal; Lithium belongs to Central Nervous System.
Why it happens
Potential additive effects on QT interval.
What to do
Consider an ECG and electrolyte check in patients with other QT risk factors or cardiac disease. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Histrelin with Lithium?
MediHelp rates the interaction as minor. Histrelin and Lithium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Histrelin is a GnRH agonist, and androgen deprivation therapies can prolong the QT interval. Lithium can also affect cardiac repolarization, so the combination may have an additive effect. The clinical significance is probably small in most patients.
How serious is the interaction between Histrelin and Lithium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an ECG and electrolyte check in patients with other QT risk factors or cardiac disease. No routine dose change is needed.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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