Drug interactions
Histrelin + Metformin
Severity: Minor
Histrelin and Metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist, suppresses sex hormones and can reduce insulin sensitivity and glucose tolerance, particularly with long-term use. This may weaken the glycemic control achieved with metformin.
What this interaction means in plain words
Histrelin and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Histrelin belongs to Musculoskeletal; Metformin belongs to Endocrine.
Why it happens
Hypogonadism induced by GnRH agonists worsens insulin resistance, opposing metformin action.
What to do
Monitor blood glucose and HbA1c during GnRH agonist therapy. Adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Histrelin with Metformin?
MediHelp rates the interaction as minor. Histrelin and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Histrelin, a GnRH agonist, suppresses sex hormones and can reduce insulin sensitivity and glucose tolerance, particularly with long-term use. This may weaken the glycemic control achieved with metformin.
How serious is the interaction between Histrelin and Metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c during GnRH agonist therapy. Adjust antidiabetic therapy if control worsens.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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