Drug interactions
Histrelin + Pimozide
Severity: Moderate
Histrelin and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist, is associated with QT prolongation due to androgen deprivation. Combined with pimozide this may raise the risk of torsades de pointes.
What this interaction means in plain words
Histrelin and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Histrelin belongs to Musculoskeletal; Pimozide belongs to Central Nervous System.
Why it happens
Additive QTc prolongation; androgen deprivation therapy may prolong the QT interval.
What to do
Obtain a baseline ECG and monitor periodically, correcting electrolytes. Consider an alternative to pimozide if the QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Histrelin with Pimozide?
MediHelp rates the interaction as moderate. Histrelin and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, a GnRH agonist, is associated with QT prolongation due to androgen deprivation. Combined with pimozide this may raise the risk of torsades de pointes.
How serious is the interaction between Histrelin and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor periodically, correcting electrolytes. Consider an alternative to pimozide if the QTc lengthens.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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