Drug interactions
Homatropine + Umeclidinium-vilanterol
Severity: Moderate
Homatropine and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Homatropine is an antimuscarinic, and when used systemically in combination cough products it adds to umeclidinium's anticholinergic effects. This may cause dry mouth, constipation, urinary retention, blurred vision and tachycardia.
What this interaction means in plain words
Homatropine and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Homatropine belongs to Genitourinary; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive blockade of muscarinic receptors.
What to do
Avoid prolonged concurrent use and monitor for urinary retention, constipation and visual symptoms. Stop the homatropine product if anticholinergic effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Homatropine and Umeclidinium-vilanterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Umeclidinium-vilanterol
Other interactions of Homatropine
- Amantadine + Homatropine Moderate
- Amitriptyline + Homatropine Moderate
- Atropine + Homatropine Moderate
- Benztropine + Homatropine Moderate
- Bethanechol + Homatropine Moderate
- Chlorpromazine + Homatropine Moderate
Frequently asked questions
Can I take Homatropine with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Homatropine and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Homatropine is an antimuscarinic, and when used systemically in combination cough products it adds to umeclidinium's anticholinergic effects. This may cause dry mouth, constipation, urinary retention, blurred vision and tachycardia.
How serious is the interaction between Homatropine and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged concurrent use and monitor for urinary retention, constipation and visual symptoms. Stop the homatropine product if anticholinergic effects emerge.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
