Drug interactions
Horse chestnut seed + Indomethacin
Severity: Minor
Horse chestnut seed and Indomethacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Horse chestnut seed extract contains aescin and, in some preparations, coumarin-like compounds that may affect coagulation. With indomethacin the risk of bleeding may theoretically be increased.
What this interaction means in plain words
Horse chestnut seed and Indomethacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive effects on hemostasis; the antiplatelet effect of indomethacin may be combined with possible anticoagulant activity of horse chestnut constituents.
What to do
Monitor for bleeding and bruising, and avoid combining with anticoagulants or in patients with GI bleeding risk. Stop the herbal product before elective surgery.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Horse chestnut seed with Indomethacin?
MediHelp rates the interaction as minor. Horse chestnut seed and Indomethacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Horse chestnut seed extract contains aescin and, in some preparations, coumarin-like compounds that may affect coagulation. With indomethacin the risk of bleeding may theoretically be increased.
How serious is the interaction between Horse chestnut seed and Indomethacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and bruising, and avoid combining with anticoagulants or in patients with GI bleeding risk. Stop the herbal product before elective surgery.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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