Drug interactions
Horse chestnut seed + Sulindac
Severity: Minor
Horse chestnut seed and Sulindac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Horse chestnut seed contains aescin and, in some preparations, coumarin-type compounds that may affect coagulation or platelets. With sulindac, a theoretical rise in bleeding risk exists.
What this interaction means in plain words
Horse chestnut seed and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive effects on hemostasis; the contribution of horse chestnut is not well established.
What to do
Counsel patients to report bleeding or bruising. Avoid combining in patients on other antithrombotics.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Horse chestnut seed with Sulindac?
MediHelp rates the interaction as minor. Horse chestnut seed and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Horse chestnut seed contains aescin and, in some preparations, coumarin-type compounds that may affect coagulation or platelets. With sulindac, a theoretical rise in bleeding risk exists.
How serious is the interaction between Horse chestnut seed and Sulindac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report bleeding or bruising. Avoid combining in patients on other antithrombotics.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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