Drug interactions
Human papillomavirus vaccine nonavalent + Prednisone
Severity: Moderate
Human papillomavirus vaccine nonavalent and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids at immunosuppressive doses may blunt antibody responses to inactivated vaccines. The vaccine is not harmful, but protection may be reduced.
What this interaction means in plain words
Human papillomavirus vaccine nonavalent and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroid immunosuppression reduces vaccine-induced immune response.
What to do
Give the vaccine when feasible before starting immunosuppression or at the lowest steroid dose. Do not delay the series unnecessarily; consider serologic follow-up where relevant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Human papillomavirus vaccine nonavalent with Prednisone?
MediHelp rates the interaction as moderate. Human papillomavirus vaccine nonavalent and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids at immunosuppressive doses may blunt antibody responses to inactivated vaccines. The vaccine is not harmful, but protection may be reduced.
How serious is the interaction between Human papillomavirus vaccine nonavalent and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine when feasible before starting immunosuppression or at the lowest steroid dose. Do not delay the series unnecessarily; consider serologic follow-up where relevant.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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