Drug interactions
Human papillomavirus vaccine quadrivalent + Procarbazine
Severity: Moderate
Human papillomavirus vaccine quadrivalent and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine-related immunosuppression may blunt the antibody response to the HPV vaccine, reducing protection.
What this interaction means in plain words
Human papillomavirus vaccine quadrivalent and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-induced immunosuppression reduces vaccine immunogenicity.
What to do
Vaccinate at least 2 weeks before starting procarbazine if feasible. Otherwise consider revaccination at least 3 months after therapy ends.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Human papillomavirus vaccine quadrivalent with Procarbazine?
MediHelp rates the interaction as moderate. Human papillomavirus vaccine quadrivalent and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine-related immunosuppression may blunt the antibody response to the HPV vaccine, reducing protection.
How serious is the interaction between Human papillomavirus vaccine quadrivalent and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before starting procarbazine if feasible. Otherwise consider revaccination at least 3 months after therapy ends.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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