Drug interactions
Human papillomavirus vaccine quadrivalent + Ustekinumab
Severity: Minor
Human papillomavirus vaccine quadrivalent and Ustekinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ustekinumab may blunt the immune response to the non-live HPV vaccine. Protection could be weaker than in untreated people.
What this interaction means in plain words
Human papillomavirus vaccine quadrivalent and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Immunomodulation through IL-12/23 inhibition may reduce vaccine immune response.
What to do
Complete the HPV series before ustekinumab if possible, but do not delay needed therapy. Continue standard cervical screening.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Frequently asked questions
Can I take Human papillomavirus vaccine quadrivalent with Ustekinumab?
MediHelp rates the interaction as minor. Human papillomavirus vaccine quadrivalent and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ustekinumab may blunt the immune response to the non-live HPV vaccine. Protection could be weaker than in untreated people.
How serious is the interaction between Human papillomavirus vaccine quadrivalent and Ustekinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete the HPV series before ustekinumab if possible, but do not delay needed therapy. Continue standard cervical screening.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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