Drug interactions
Hyaluronidase + Promethazine
Severity: Minor
Hyaluronidase and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labeling for hyaluronidase notes that antihistamines at large systemic doses may make tissues partly resistant to its spreading action. A larger dose of hyaluronidase may be needed to achieve the desired dispersion.
What this interaction means in plain words
Hyaluronidase and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hyaluronidase belongs to Miscellaneous; Promethazine belongs to Respiratory.
Why it happens
Antihistamines are reported to reduce tissue responsiveness to hyaluronidase; the exact mechanism is not established.
What to do
Assess the dispersing effect of hyaluronidase and increase the dose if response is inadequate in patients on high-dose promethazine. No action is needed for routine low doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Other interactions of Hyaluronidase
Frequently asked questions
Can I take Hyaluronidase with Promethazine?
MediHelp rates the interaction as minor. Hyaluronidase and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Labeling for hyaluronidase notes that antihistamines at large systemic doses may make tissues partly resistant to its spreading action. A larger dose of hyaluronidase may be needed to achieve the desired dispersion.
How serious is the interaction between Hyaluronidase and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess the dispersing effect of hyaluronidase and increase the dose if response is inadequate in patients on high-dose promethazine. No action is needed for routine low doses.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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