Drug interactions
Hydralazine + Ibuprofen
Severity: Moderate
Hydralazine and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the blood-pressure-lowering effect of hydralazine, especially with regular use. Sodium and water retention may also contribute to loss of control.
What this interaction means in plain words
Hydralazine and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydralazine belongs to Cardiovascular; Ibuprofen belongs to Musculoskeletal.
Why it happens
Inhibition of vasodilatory prostaglandin synthesis and renal sodium and water retention oppose the antihypertensive effect.
What to do
Monitor blood pressure when ibuprofen is used regularly and use the lowest effective NSAID dose for the shortest time; consider paracetamol as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Ibuprofen?
MediHelp rates the interaction as moderate. Hydralazine and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the blood-pressure-lowering effect of hydralazine, especially with regular use. Sodium and water retention may also contribute to loss of control.
How serious is the interaction between Hydralazine and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when ibuprofen is used regularly and use the lowest effective NSAID dose for the shortest time; consider paracetamol as an alternative.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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