Drug interactions
Hydralazine + Isocarboxazid
Severity: Moderate
Hydralazine and Isocarboxazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can cause orthostatic hypotension and may enhance the effect of vasodilating antihypertensives such as hydralazine. Excessive blood pressure reduction and dizziness or falls may occur.
What this interaction means in plain words
Hydralazine and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydralazine belongs to Cardiovascular; Isocarboxazid belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from MAO inhibitor autonomic effects and hydralazine vasodilation.
What to do
Monitor blood pressure, including standing readings, when starting or adjusting either drug. Reduce the hydralazine dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Hydralazine with Isocarboxazid?
MediHelp rates the interaction as moderate. Hydralazine and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can cause orthostatic hypotension and may enhance the effect of vasodilating antihypertensives such as hydralazine. Excessive blood pressure reduction and dizziness or falls may occur.
How serious is the interaction between Hydralazine and Isocarboxazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including standing readings, when starting or adjusting either drug. Reduce the hydralazine dose if symptomatic hypotension occurs.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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