Drug interactions
Hydralazine + Meclofenamic acid
Severity: Moderate
Hydralazine and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may blunt the blood pressure lowering effect of hydralazine through fluid retention and prostaglandin inhibition. The effect varies between patients.
What this interaction means in plain words
Hydralazine and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydralazine belongs to Cardiovascular; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory prostaglandins and sodium and water retention oppose vasodilator action.
What to do
Monitor blood pressure when NSAID therapy is started or stopped and adjust the antihypertensive regimen if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydralazine and Meclofenamic acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Meclofenamic acid?
MediHelp rates the interaction as moderate. Hydralazine and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may blunt the blood pressure lowering effect of hydralazine through fluid retention and prostaglandin inhibition. The effect varies between patients.
How serious is the interaction between Hydralazine and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when NSAID therapy is started or stopped and adjust the antihypertensive regimen if needed.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
