Drug interactions
Hydralazine + Minoxidil
Severity: Moderate
Hydralazine and Minoxidil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are direct arteriolar vasodilators, so combining them can produce excessive hypotension and marked reflex tachycardia with fluid retention. They are rarely combined, and only in resistant hypertension.
What this interaction means in plain words
Hydralazine and Minoxidil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydralazine belongs to Cardiovascular; Minoxidil belongs to Cardiovascular.
Why it happens
Additive direct arteriolar vasodilation.
What to do
Monitor blood pressure, heart rate and fluid status. Use with a beta blocker and diuretic as indicated, and reduce doses if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Other interactions of Minoxidil
Frequently asked questions
Can I take Hydralazine with Minoxidil?
MediHelp rates the interaction as moderate. Hydralazine and Minoxidil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are direct arteriolar vasodilators, so combining them can produce excessive hypotension and marked reflex tachycardia with fluid retention. They are rarely combined, and only in resistant hypertension.
How serious is the interaction between Hydralazine and Minoxidil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and fluid status. Use with a beta blocker and diuretic as indicated, and reduce doses if hypotension occurs.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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