Drug interactions
Hydralazine + Naproxen
Severity: Minor
Hydralazine and Naproxen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen may blunt the blood pressure lowering effect of hydralazine through fluid retention. The effect is usually modest but can matter in patients with poorly controlled hypertension.
What this interaction means in plain words
Hydralazine and Naproxen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydralazine belongs to Cardiovascular; Naproxen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory prostaglandins promotes sodium and water retention and opposes vasodilation.
What to do
Monitor blood pressure when naproxen is started or stopped and adjust antihypertensive therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Naproxen?
MediHelp rates the interaction as minor. Hydralazine and Naproxen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Naproxen may blunt the blood pressure lowering effect of hydralazine through fluid retention. The effect is usually modest but can matter in patients with poorly controlled hypertension.
How serious is the interaction between Hydralazine and Naproxen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when naproxen is started or stopped and adjust antihypertensive therapy if needed.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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