Drug interactions
Hydralazine + Pseudoephedrine
Severity: Moderate
Hydralazine and Pseudoephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pseudoephedrine can raise blood pressure and counteract the antihypertensive effect of hydralazine. Reflex sympathetic activation from hydralazine may compound tachycardia.
What this interaction means in plain words
Hydralazine and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydralazine belongs to Cardiovascular; Pseudoephedrine belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism: sympathomimetic vasoconstriction and pressor effect oppose vasodilation.
What to do
Monitor blood pressure when pseudoephedrine is started or used regularly; avoid it in poorly controlled hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pseudoephedrine
- Isocarboxazid + Pseudoephedrine Contraindicated
- Phenelzine + Pseudoephedrine Contraindicated
- Pseudoephedrine + Rasagiline Contraindicated
- Pseudoephedrine + Selegiline Contraindicated
- Pseudoephedrine + Selegiline transdermal Contraindicated
- Pseudoephedrine + Tranylcypromine Contraindicated
Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Pseudoephedrine?
MediHelp rates the interaction as moderate. Hydralazine and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pseudoephedrine can raise blood pressure and counteract the antihypertensive effect of hydralazine. Reflex sympathetic activation from hydralazine may compound tachycardia.
How serious is the interaction between Hydralazine and Pseudoephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when pseudoephedrine is started or used regularly; avoid it in poorly controlled hypertension.
What other medicines interact with Pseudoephedrine?
MediHelp also lists interactions of Pseudoephedrine with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Pseudoephedrine page.
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