Drug interactions
Hydralazine + Timolol
Severity: Moderate
Hydralazine and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The two drugs lower blood pressure by different mechanisms and are often combined deliberately. Beta-blockers blunt hydralazine's reflex tachycardia, but the combination can cause excess hypotension.
What this interaction means in plain words
Hydralazine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydralazine belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effect from beta-blockade and direct arteriolar vasodilation.
What to do
Monitor blood pressure and heart rate and titrate doses gradually. Watch for orthostatic symptoms, particularly at initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Timolol?
MediHelp rates the interaction as moderate. Hydralazine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The two drugs lower blood pressure by different mechanisms and are often combined deliberately. Beta-blockers blunt hydralazine's reflex tachycardia, but the combination can cause excess hypotension.
How serious is the interaction between Hydralazine and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and titrate doses gradually. Watch for orthostatic symptoms, particularly at initiation.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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