Drug interactions
Hydrochlorothiazide-losartan + Insulin degludec / insulin aspart
Severity: Minor
Hydrochlorothiazide-losartan and Insulin degludec / insulin aspart: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Losartan may modestly increase insulin sensitivity and the hypoglycemic effect of insulin, whereas hydrochlorothiazide can cause hyperglycemia. The net effect on glycemic control can vary between patients.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Insulin degludec / insulin aspart have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Angiotensin receptor blockade may enhance insulin sensitivity, whereas thiazide-induced hypokalemia and reduced insulin secretion raise glucose.
What to do
Monitor blood glucose when the antihypertensive is started, changed or stopped and adjust the insulin dose accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Insulin degludec / insulin aspart?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Insulin degludec / insulin aspart have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Losartan may modestly increase insulin sensitivity and the hypoglycemic effect of insulin, whereas hydrochlorothiazide can cause hyperglycemia. The net effect on glycemic control can vary between patients.
How serious is the interaction between Hydrochlorothiazide-losartan and Insulin degludec / insulin aspart?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when the antihypertensive is started, changed or stopped and adjust the insulin dose accordingly.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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