Drug interactions
Hydrochlorothiazide-losartan + Insulin isophane human / insulin regular human
Severity: Minor
Hydrochlorothiazide-losartan and Insulin isophane human / insulin regular human: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Losartan can improve insulin sensitivity and occasionally increase the risk of hypoglycemia in insulin-treated patients, whereas hydrochlorothiazide may raise glucose. Overall glycemic effects are usually small.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Insulin isophane human / insulin regular human have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Angiotensin receptor blockade may improve insulin sensitivity, while thiazide diuretics may impair glucose tolerance.
What to do
Monitor blood glucose after starting or changing the antihypertensive and adjust the insulin dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-losartan and Insulin isophane human / insulin regular human, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Insulin isophane human / insulin regular human?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Insulin isophane human / insulin regular human have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Losartan can improve insulin sensitivity and occasionally increase the risk of hypoglycemia in insulin-treated patients, whereas hydrochlorothiazide may raise glucose. Overall glycemic effects are usually small.
How serious is the interaction between Hydrochlorothiazide-losartan and Insulin isophane human / insulin regular human?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing the antihypertensive and adjust the insulin dose if needed.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
