Drug interactions
Hydrochlorothiazide-losartan + Juniper
Severity: Moderate
Hydrochlorothiazide-losartan and Juniper: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Juniper berry preparations have traditionally been used for their diuretic effect and may add to the fluid and electrolyte loss caused by hydrochlorothiazide. This could contribute to volume depletion, electrolyte disturbance or kidney stress, especially with large doses. Clinical data are scarce.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Juniper can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive diuretic effect; juniper may also irritate the kidneys at high doses.
What to do
Advise patients to avoid juniper supplements while on this combination. If used, monitor blood pressure, electrolytes and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Juniper?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Juniper can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Juniper berry preparations have traditionally been used for their diuretic effect and may add to the fluid and electrolyte loss caused by hydrochlorothiazide. This could contribute to volume depletion, electrolyte disturbance or kidney stress, especially with large doses. Clinical data are scarce.
How serious is the interaction between Hydrochlorothiazide-losartan and Juniper?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid juniper supplements while on this combination. If used, monitor blood pressure, electrolytes and renal function.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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