Drug interactions
Hydrochlorothiazide-losartan + Levalbuterol
Severity: Moderate
Hydrochlorothiazide-losartan and Levalbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both levalbuterol and hydrochlorothiazide can lower serum potassium. Together they may cause clinically significant hypokalemia, particularly with high-dose or frequent bronchodilator use, with a risk of arrhythmia. Losartan may partly offset this by raising potassium.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Levalbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 agonists shift potassium into cells while thiazides increase renal potassium loss, producing additive hypokalemia.
What to do
Monitor serum potassium in patients using frequent or high-dose levalbuterol, and replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Levalbuterol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Levalbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both levalbuterol and hydrochlorothiazide can lower serum potassium. Together they may cause clinically significant hypokalemia, particularly with high-dose or frequent bronchodilator use, with a risk of arrhythmia. Losartan may partly offset this by raising potassium.
How serious is the interaction between Hydrochlorothiazide-losartan and Levalbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients using frequent or high-dose levalbuterol, and replace potassium as needed.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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