Drug interactions
Hydrochlorothiazide-losartan + Lily of the valley
Severity: Major
Hydrochlorothiazide-losartan and Lily of the valley: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lily of the valley contains cardiac glycosides. Hydrochlorothiazide can cause hypokalemia and hypomagnesemia, which increases the risk of glycoside toxicity and arrhythmia.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Lily of the valley can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Thiazide-induced potassium and magnesium depletion sensitizes the myocardium to cardiac glycoside effects.
What to do
Avoid lily of the valley products. If exposure occurs, check potassium, magnesium and ECG and correct any deficits.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Lily of the valley?
MediHelp rates the interaction as major. Hydrochlorothiazide-losartan and Lily of the valley can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lily of the valley contains cardiac glycosides. Hydrochlorothiazide can cause hypokalemia and hypomagnesemia, which increases the risk of glycoside toxicity and arrhythmia.
How serious is the interaction between Hydrochlorothiazide-losartan and Lily of the valley?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid lily of the valley products. If exposure occurs, check potassium, magnesium and ECG and correct any deficits.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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