Drug interactions
Hydrochlorothiazide-losartan + Magnesium sulfate
Severity: Minor
Hydrochlorothiazide-losartan and Magnesium sulfate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide increases urinary magnesium loss and can lower serum magnesium, partly opposing magnesium sulfate therapy. Hypomagnesemia from thiazides is also a risk factor for arrhythmia.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Magnesium sulfate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazide-induced increase in renal magnesium excretion.
What to do
Monitor serum magnesium and potassium and adjust magnesium dosing to the measured level.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Magnesium sulfate?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Magnesium sulfate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide increases urinary magnesium loss and can lower serum magnesium, partly opposing magnesium sulfate therapy. Hypomagnesemia from thiazides is also a risk factor for arrhythmia.
How serious is the interaction between Hydrochlorothiazide-losartan and Magnesium sulfate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and potassium and adjust magnesium dosing to the measured level.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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