Drug interactions
Hydrochlorothiazide-losartan + Methyclothiazide
Severity: Moderate
Hydrochlorothiazide-losartan and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination product already contains a thiazide diuretic, so adding methyclothiazide is therapeutic duplication. This increases the risk of excessive diuresis, hypotension, hyponatremia, hypokalemia and renal impairment.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Duplicate thiazide action at the distal convoluted tubule produces additive diuresis and electrolyte loss.
What to do
Avoid using two thiazides together. If combined deliberately, monitor electrolytes, renal function and blood pressure closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Methyclothiazide?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination product already contains a thiazide diuretic, so adding methyclothiazide is therapeutic duplication. This increases the risk of excessive diuresis, hypotension, hyponatremia, hypokalemia and renal impairment.
How serious is the interaction between Hydrochlorothiazide-losartan and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two thiazides together. If combined deliberately, monitor electrolytes, renal function and blood pressure closely.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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