Drug interactions
Hydrochlorothiazide-losartan + Methylphenidate transdermal
Severity: Moderate
Hydrochlorothiazide-losartan and Methylphenidate transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylphenidate can raise blood pressure and heart rate, and may reduce the effectiveness of antihypertensive therapy. Blood pressure control with losartan and hydrochlorothiazide may be worse.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Methylphenidate transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sympathomimetic pressor effect of methylphenidate opposes the antihypertensive action.
What to do
Monitor blood pressure when starting or adjusting methylphenidate and adjust the antihypertensive regimen if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-losartan and Methylphenidate transdermal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Methylphenidate transdermal?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Methylphenidate transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methylphenidate can raise blood pressure and heart rate, and may reduce the effectiveness of antihypertensive therapy. Blood pressure control with losartan and hydrochlorothiazide may be worse.
How serious is the interaction between Hydrochlorothiazide-losartan and Methylphenidate transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or adjusting methylphenidate and adjust the antihypertensive regimen if control is lost.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
