Drug interactions
Hydrochlorothiazide-losartan + Miconazole vaginal
Severity: Minor
Hydrochlorothiazide-losartan and Miconazole vaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic absorption of vaginal miconazole is low, but miconazole inhibits CYP2C9 and CYP3A4, and interactions with warfarin have been reported. An effect on losartan activation is theoretically possible but unlikely to be clinically important.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Miconazole inhibits CYP2C9 and CYP3A4, which could reduce losartan conversion to its active metabolite if absorbed systemically.
What to do
No routine adjustment is needed; monitor blood pressure if prolonged or repeated use occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Miconazole vaginal?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic absorption of vaginal miconazole is low, but miconazole inhibits CYP2C9 and CYP3A4, and interactions with warfarin have been reported. An effect on losartan activation is theoretically possible but unlikely to be clinically important.
How serious is the interaction between Hydrochlorothiazide-losartan and Miconazole vaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor blood pressure if prolonged or repeated use occurs.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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