Drug interactions
Hydrochlorothiazide-losartan + Mipomersen
Severity: Moderate
Hydrochlorothiazide-losartan and Mipomersen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen can cause elevated transaminases and hepatic steatosis. Losartan has been associated with rare liver enzyme elevations, so liver monitoring is relevant when they are used together.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Potential additive hepatotoxicity; no pharmacokinetic mechanism is established.
What to do
Monitor liver enzymes and bilirubin as required by mipomersen labeling, and review therapy if persistent elevations occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Mipomersen?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen can cause elevated transaminases and hepatic steatosis. Losartan has been associated with rare liver enzyme elevations, so liver monitoring is relevant when they are used together.
How serious is the interaction between Hydrochlorothiazide-losartan and Mipomersen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and bilirubin as required by mipomersen labeling, and review therapy if persistent elevations occur.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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