Drug interactions
Hydrochlorothiazide-losartan + Mycophenolate
Severity: Minor
Hydrochlorothiazide-losartan and Mycophenolate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides and mycophenolic acid glucuronide are both handled by renal tubular secretion, so competition might modestly raise exposure to the mycophenolate glucuronide. The clinical significance is uncertain.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Mycophenolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular anionic transport between hydrochlorothiazide and mycophenolate metabolites.
What to do
No routine change is needed; monitor for mycophenolate adverse effects such as cytopenias and gastrointestinal symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-losartan and Mycophenolate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Mycophenolate?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Mycophenolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides and mycophenolic acid glucuronide are both handled by renal tubular secretion, so competition might modestly raise exposure to the mycophenolate glucuronide. The clinical significance is uncertain.
How serious is the interaction between Hydrochlorothiazide-losartan and Mycophenolate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor for mycophenolate adverse effects such as cytopenias and gastrointestinal symptoms.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
