Drug interactions
Hydrochlorothiazide-losartan + Nafcillin
Severity: Minor
Hydrochlorothiazide-losartan and Nafcillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is an inducer of drug-metabolizing enzymes and could in theory lower exposure to losartan and its active metabolite, weakening blood pressure control. The clinical relevance is not well documented and the renal competition suggested for hydrochlorothiazide is minor.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible enzyme induction by nafcillin increasing losartan clearance; the effect is largely theoretical.
What to do
No routine dose change is needed; check blood pressure when nafcillin is started or stopped during prolonged courses and adjust the antihypertensive if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-losartan and Nafcillin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Nafcillin?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nafcillin is an inducer of drug-metabolizing enzymes and could in theory lower exposure to losartan and its active metabolite, weakening blood pressure control. The clinical relevance is not well documented and the renal competition suggested for hydrochlorothiazide is minor.
How serious is the interaction between Hydrochlorothiazide-losartan and Nafcillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; check blood pressure when nafcillin is started or stopped during prolonged courses and adjust the antihypertensive if control is lost.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
