Drug interactions
Hydrochlorothiazide-losartan + Nefazodone
Severity: Minor
Hydrochlorothiazide-losartan and Nefazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone strongly inhibits CYP3A4, which may modestly alter losartan activation and clearance. Losartan relies mainly on CYP2C9 and CYP3A4 so the effect is unpredictable and likely small. Nefazodone itself can cause hypotension and orthostasis, which may add to the antihypertensive effect.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Nefazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 inhibition by nefazodone, with additive hypotensive effects from its alpha-1 blocking activity.
What to do
Monitor blood pressure and orthostatic symptoms when starting or stopping nefazodone; adjust the antihypertensive dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-losartan and Nefazodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Nefazodone?
MediHelp rates the interaction as minor. Hydrochlorothiazide-losartan and Nefazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nefazodone strongly inhibits CYP3A4, which may modestly alter losartan activation and clearance. Losartan relies mainly on CYP2C9 and CYP3A4 so the effect is unpredictable and likely small. Nefazodone itself can cause hypotension and orthostasis, which may add to the antihypertensive effect.
How serious is the interaction between Hydrochlorothiazide-losartan and Nefazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or stopping nefazodone; adjust the antihypertensive dose if needed.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
