Drug interactions
Hydrochlorothiazide-losartan + Nitroglycerin rectal
Severity: Moderate
Hydrochlorothiazide-losartan and Nitroglycerin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroglycerin causes venous and arterial vasodilation, and combined with losartan and a thiazide diuretic it can produce additive hypotension. Dizziness, syncope and falls are more likely, especially in volume-depleted or older patients.
What this interaction means in plain words
Hydrochlorothiazide-losartan and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic vasodilation and volume reduction lowering blood pressure.
What to do
Monitor blood pressure, particularly after the first doses, and counsel patients to rise slowly; reduce doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-losartan with Nitroglycerin rectal?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-losartan and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitroglycerin causes venous and arterial vasodilation, and combined with losartan and a thiazide diuretic it can produce additive hypotension. Dizziness, syncope and falls are more likely, especially in volume-depleted or older patients.
How serious is the interaction between Hydrochlorothiazide-losartan and Nitroglycerin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, particularly after the first doses, and counsel patients to rise slowly; reduce doses if symptomatic hypotension occurs.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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